Hematology
Hematology
The Complex Operative Unit (C.O.U.) of Hematology provides both inpatient and outpatient services, offering advanced diagnostic procedures and innovative treatments aligned with national and international guidelines as well as active clinical protocols.
The unit primarily addresses hematologic malignancies, including:
- Leukemias
- Lymphomas
- Multiple Myeloma
- Myelodysplastic Syndromes
- Chronic Myeloproliferative Syndromes
- Acute Leukemias: Conventional chemotherapy protocols and targeted therapies.
- Lymphomas: Induction chemotherapy, high-dose regimens with Peripheral Stem Cell Collection, and targeted therapies.
- Multiple Myeloma: Induction chemotherapy, high-dose regimens with Peripheral Stem Cell Collection, and targeted therapies.
- Myelodysplastic Syndromes: Hypomethylating agents.
- Chronic Myeloproliferative Syndromes: Latest-generation Tyrosine Kinase Inhibitors (TKIs) and JAK2 inhibitors.
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It also treats rare non-malignant disorders such as Thrombotic Thrombocytopenic Purpura (TTP) and Idiopathic Thrombocytopenic Purpura (ITP) using state-of-the-art therapies. In the Day Hospital and Day Service, the unit administers chemotherapy, immunotherapy, and transfusion support with blood derivatives.
At the outpatient clinic, patients receive initial consultations, follow-up visits after treatment, and long-term survivor care. The Division’s clinical activities are supported by a cutting-edge laboratory equipped for: Cytology, Flow cytometry with 8- and 10-fluorescence platforms, Traditional cytogenetics, Molecular cytogenetics (FISH), Chimerism studies using STR and FISH techniques, Qualitative and quantitative molecular biology (PCR, Sanger sequencing, and NGS).
For research purposes, the laboratory specializes in Minimal Residual Disease (MRD) detection through NGS, mass cytometry (viSNE), and RNA analysis for studying specific proteins in T-cell Acute Lymphoblastic Leukemia (T-ALL). The Scientific Trial Office oversees approximately 100 clinical and biological research protocols, offering patients access to cutting-edge therapies not yet available in the National Health System (SSN).
The Division is deeply integrated into all major national and international scientific networks and plays an active role in the Apulian Hematology Network.
The inpatient unit includes 23 beds, managing over 1,500 hospitalizations annually, with approximately 25% of patients coming from outside the region. The Day Hospital and outpatient clinic provide care for more than 40 patients daily.
Doctors
Dr. Carella Angelo Michele
Dr.ssa Abbenante Maria Chiara
Dr. Rossi Giovanni
Dr.ssa Merla Emanuela
Dr. Mantuano Francesco Saverio
Dr.ssa Sanpaolo Grazia
Dr.ssa Falcone Antonietta Pia
Dr. Totaro Matteo
Dr. D' Agostino Francesco

Head of Operative Unit:
Dr. Angelo Michele Carella
Operative Unit Contacts
Secretariat
0882 410224
Nursing Station
0882 410295 - 0882 410566
Day Hospital
0882 416370
Clinical Trial Office
0882 410022
Medical Sciences Department
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